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Thursday, October 18, 2012

Next-gen Casio G'zOne makes it to the FCC, reveals LTE and NFC support

The last Casio G'zOne handheld to come our way was the Commando, a military-grade device that marked the company's first foray into Android smartphones. Now it seems there's another one in the works, at least if a recent FCC filing is any indication. The Casio C811 looks to be a successor to the aforementioned Commando, with its G'zOne branding and features like WiFi and GSM world phone capabilities. Notably, the FCC document reveals the phone has Verizon-flavored LTE plus NFC support, both of which lead us to believe it'll likely be a mid- to high-end handset. Not much else is divulged from perusing the filing, but we're sure that whatever the C811 turns out to be, it'll be just as tough and durable as the rest of Casio's G'zOne offerings.

Filed under: Cellphones, Mobile, Verizon

Next-gen Casio G'zOne makes it to the FCC, reveals LTE and NFC support originally appeared on Engadget on Thu, 18 Oct 2012 08:38:00 EDT. Please see our terms for use of feeds.

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New insights into how genetic differences influence breast cancer risk from low-dose radiation

ScienceDaily (Oct. 16, 2012) ? Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have identified tissue mechanisms that may influence a woman's susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

The research could lead to new ways to identify women who have higher or lower risks of breast cancer from low-dose radiation. Such a predictive tool could help guide the treatment of cancer patients who may be better served by non-radiation therapies.

The findings also support the idea that a person's genes play a big role in determining her risk of breast cancer from low-dose radiation. The current model for predicting cancer risk from ionizing radiation holds that risk is directly proportional to dose. But there's a growing understanding that this linear relationship doesn't apply at lower doses. Instead, the health effects of low-dose radiation may vary substantially among people depending on their genetic makeup.

The scientists, led by Andy Wyrobek of Berkeley Lab's Life Sciences Division, report their research October 15 in the journal PLOS ONE.

They studied mammary tissue from two strains of mice -- one that is susceptible to radiation-induced mammary gland cancer and one that is resistant -- before and after the mice were exposed to low-dose radiation.

The team then looked for differences between the two strains in how their genes turn on and off. They used a method that scans thousands of genes simultaneously. They found differences in genes that regulate tissue stress response, DNA repair, immune response, cellular proliferation, and other cellular and tissue mechanisms.

They also found that these differences carried over to breast cancer survivability in women. Breast cancer patients with gene expression profiles like the cancer-resistant mice (before radiation exposure) were more likely to survive eight years after diagnosis. Women with gene expression profiles like the cancer-sensitive mice were less likely to survive after eight years.

Based on this, the scientists believe the cellular and tissue mechanisms that control mice's risk of mammary gland cancer from low-dose radiation are similar to the mechanisms that affect a woman's chance of surviving breast cancer.

"Our studies of genetic differences in radiation sensitivity in mice, and individual variation in breast cancer survival in women, suggest that there are women who, because of their genes, have a higher risk of breast cancer when they're exposed to low-dose radiation," says Andy Wyrobek, who conducted the research with Antoine Snijders, Joe Gray, and several other Berkeley Lab scientists.

"This raises the possibility that we can use gene expression profiles to develop simple tests that screen for women who may be sensitive to low-dose radiation versus women who are resistant," Snijders says.

The scientists first studied mice before radiation exposure. They found more than 130 genes that express differently in blood and mammary tissue samples of cancer-resistant mice compared to cancer-sensitive mice.

To determine if these differences also apply to people, the scientists mined human breast cancer "knowledge bases" that link the expression of patients' tumor genes with their survival outcomes. They studied newly diagnosed women before they received radiation or chemical therapies. Women with gene expression levels like those of radiation-sensitive mice were less likely to survive after eight years. In contrast, women with expression levels like those of the resistant strain were more likely to survive the eight-year duration of the follow-up.

Next, gene expression analyses conducted a few hours after the end of low-dose exposure found changes in many genes in the mammary tissue of cancer-sensitive mice. Large numbers of genes that regulate their immune system were suppressed, while genes that regulate pubertal mammary gland development were turned on in error. In cancer-resistant mice, these genes showed only a small change in activity.

Analyses conducted one month after exposure yielded striking differences in the expression of a large set of genes that control cell proliferation. The cancer-sensitive mice had up-regulated many genes associated with cell division and cell renewal. The cancer-resistant mice had down-regulated these same genes below normal levels, which suggests they were able to activate tissue mechanisms that prevent cellular proliferation that can lead to cancer.

These differences again carried over to people. Breast cancer patients whose cell division and renewal genes were up-regulated like the cancer-sensitive mice didn't survive as long as patients in which the same genes were suppressed.

The scientists are now refining these gene expression signatures by studying large groups of women with breast cancer. They're also testing the mechanisms by which these signatures control radiation sensitivity using special breast cell culture models developed at Berkeley Lab.

"This research opens promising opportunities for developing blood tests that predict a woman's risk for breast cancer, and which identify women who are susceptible to the cancer effects of low-dose radiation exposures," says Wyrobek.

This research was supported by Berkeley Lab's Laboratory Directed Research and Development fund and the Department of Energy's Office of Science.

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Story Source:

The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Antoine M. Snijders, Francesco Marchetti, Sandhya Bhatnagar, Nadire Duru, Ju Han, Zhi Hu, Jian-Hua Mao, Joe W. Gray, Andrew J. Wyrobek. Genetic Differences in Transcript Responses to Low-Dose Ionizing Radiation Identify Tissue Functions Associated with Breast Cancer Susceptibility. PLoS ONE, 2012; 7 (10): e45394 DOI: 10.1371/journal.pone.0045394

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/_txV3vrrk7I/121017091932.htm

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Are Stocks Undervalued? - Zacks Investment Research

A key point on the U.S. stock market flows from the so-called "FED" model.

It is called the FED model because this is a model the Federal Reserve uses.

What it says is that if you flip the Price-Earnings (P/E) valuation ratio for S&P 500 stocks upside down (to E/P), you effectively have an implied cash flow yield on stocks, much like an interest rate.

If you think that annual stock cash flow returns should track annual bond interest rate returns, then you understand the logic of this model. The two major asset class cash flow returns should track one another, as investors seek the best place to put money to work. No opportunities to arbitrage are left on the table.

In terms of the FED model then, the E/P ratio of stocks should track some widely accepted benchmark in long-term interest rates. In the eyes of most people, this is the 10-year U.S. Treasury rate.

See below ? the Treasury 10-yr bond rate is purple; the S&P500 E/P ratio is red.

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What does a person find when you look at this relationship?

It held together reasonably well from 1981 until 1999, when stock market valuation went on a big rise, tracking a downward path of long-term interest rates. However, perhaps since 1999, and certainly since the 2008 financial chaos, this yield relationship has broken down.

Since 2008, it is not true these relationships track one another.

For example, as the chart in this article shows (with the purple line), we have had the 10-year U.S. Treasury interest rate decline from around 4.5% in 2000 to around 2.0% today. The corresponding E/P ratio for stocks (which is the red line) should have gone down with it, meaning a big rise in stocks. Instead, the red line E/P ratio has gone from something like 4.5% to something near 7%.

The Key Point: Sitting in Q4, the FED earnings valuation model implies there is much more yield to be had from owning a stock than a bond.

Forecasts for the 10-year U.S. Treasury offer 50-75 basis points more yield over the coming year. Zero rates are forecast at short-end maturities for at least two more years. It appears unlikely much incentive is in place to move into fixed-income securities coming purely from interest rates they pay. Since 2008, the real attraction to all maturities of fixed income is preserving capital: Safe Haven.

To restore this historic relationship between stock and bond yields, we need to see the 10-year risk-free U.S. Treasury rate start rising again. And stock prices in the S&P 500 index race ahead of annual earnings growth rates.

In other words, revived demand for long-term finance needs to happen in the bond market (i.e. strong loan demand), and a valuation, or P/E multiple expansion, needs to happen to the stock market (i.e. optimism).

Stronger-than-expected payrolls and an uptick in real GDP growth would do the trick.

For Q3, we have seen a pick-up in bank earnings from stronger mortgage loan making. And some of the highest consumer confidence numbers in four years. This FED model may start to gain a little traction. At the least, the latest S&P 500 earnings numbers in the FED model context offer another bullish sign.

The FED model shows U.S. equity markets can run for some time until this historic earnings yield relationship is restored.

Happy Investing! John Blank

John Blank is Chief Equity Strategist at Zacks. He provides a critically analytical view of the markets and the forces driving them. With the FED model providing bullish signals, now is a perfect time to see for yourself all of the services Zacks offers. From long-term investment strategies to short-term trading alerts, we offer a service to match your portfolio goals and risk tolerance. The best way to discover all we have to offer is with our Zacks Ultimate service. You?ll see first-hand all of the trades, picks, and insightful commentary of all of our editors. And then you can decide for yourself which is best for you.

Learn more about Zacks Ultimate now.

Source: http://www.zacks.com/commentary/24108/are-stocks-undervalued

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Wednesday, October 17, 2012

Study questions feasibility of entire genome sequencing in minutes

ScienceDaily (Oct. 17, 2012) ? The claim that nanopore technology is on the verge of making DNA analysis so fast and cheap that a person's entire genome could be sequenced in just minutes and at a fraction of the cost of available commercial methods, has resulted in overwhelming academic, industrial, and global interest. But a review by Northeastern University physicist Meni Wanunu, published in a special issue on nanopore sequencing in Physics of Life Reviews, questions whether the remaining technical hurdles can be overcome to create a workable, easily produced commercial device.

Earlier this year Oxford Nanopore Technologies, one of the pioneering companies of sequencing discoveries, announced that they expect nanopore strand sequencing to achieve a 15-minute genome by 2014 at a cost of $1,500. This is a far cry from the $10 million it cost to sequence an entire genome just 5 years ago.

Since the idea of nanopore sequencing was first proposed in the mid 1990s, huge advances have been made. The basic idea is exceedingly simple: a single thread of DNA is passed through a tiny molecule-sized hole-or nanopore-and the various DNA bases are identified in sequence as they move through the pore.

But according to Wanunu, the reality of manipulating technology based on pores so tiny that 25,000 of them can fit side by side on a human hair has proved a daunting task. The main challenge has been to slow the process down and control the movement of the DNA strand through the pore at a rate slow enough to make individual DNA bases readable and usable. A new approach using enzyme-controlled movement, developed to overcome this problem, has its own drawbacks including poor enzyme activity resulting in limited processivity and uncontrolled forward-reverse motion.

Another major dilemma has been whether protein or solid-state pores provide the most promising technique. At first, naturally occurring porous proteins were investigated. But in the early 2000s, heralded as offering better capability and flexibility, various solid-state nanopores made of silicon or graphene were tested. "Since both lipid-embedded protein channels and solid-state nanopores have drawbacks, it will be interesting to see which device, or what combination of devices, will be available in years to come, if any," Wanunu says.

At this time there are still many hurdles to overcome, he adds, including the inability of nanopores to provide any spectroscopic information about the identity of a molecule, uncertainties about whether translocation occurs at a constant speed, and the complications of pore clogging.

Writing in a comment published in the same issue, John Kasianowicz from the National Institute of Standards and Technology in the US, a pioneer in the field, agrees that plenty of challenges remain: "There are indeed still many problems to address in order to enable practical electronic nanopore-based sensing devices. However, by better understanding the road already developed in this nascent field, the journey will hopefully appear a little less daunting."

In a final comment on Wanunu's review, the founder and Director of Oxford Nanopore, Hagan Bayley, looks ahead to the future: "In the longer term, by using solid-state pores... it may be possible to read DNA sequences at microseconds rather than milliseconds per base. This could be done by using tunnelling currents or other characteristics of the DNA bases for which graphene-with its unusual electronic properties-might after additional development provide a superior substrate and in so doing deliver another massive leap forward on top of a decade of unprecedented progress."

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The above story is reprinted from materials provided by Elsevier, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal References:

John J. Kasianowicz. Bio-inspired nanopore-based sensors. Physics of Life Reviews, 2012; 9 (2): 170 DOI: 10.1016/j.plrev.2012.05.012
Hagan Bayley. Are we there yet? Physics of Life Reviews, 2012; 9 (2): 161 DOI: 10.1016/j.plrev.2012.05.015

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/XXJQeWvRyaQ/121017091751.htm

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Decades late, FDR memorial park is opening in NYC

This Aug. 24, 2012 photo provided by FDR Four Freedoms Park LLC, shows the New York City memorial park, honoring President Franklin D. Roosevelt, that has been completed 40 years after the original design was created. The Franklin D. Roosevelt Four Freedoms Park on the southern tip of 2-mile-long Roosevelt Island - between Manhattan and Queens - is being dedicated Wednesday, Oct. 17, 2012, in a ceremony to be attended by dignitaries including former President Bill Clinton and Mayor Michael Bloomberg. (AP Photo/FDR Four Freedoms Park LLC, Paul Warchol)

This July 11, 2012 photo provided by FDR Four Freedoms Park LLC, shows an arial view of the New York City memorial park, honoring President Franklin D. Roosevelt, that has been completed 40 years after the original design was created. The Franklin D. Roosevelt Four Freedoms Park on the southern tip of 2-mile-long Roosevelt Island - between Manhattan and Queens - is being dedicated Wednesday, Oct. 17, 2012, in a ceremony to be attended by dignitaries including former President Bill Clinton and Mayor Michael Bloomberg. (AP Photo/FDR Four Freedoms Park LLC, Steve Amiaga - www.amiaga.com)

NEW YORK (AP) ? It's been nearly 40 years since New York City started planning a memorial to President Franklin Roosevelt on an island in the East River. Welfare Island was renamed Roosevelt Island, and American architect Louis Kahn was commissioned to design a park honoring the 32nd president.

The memorial park was never realized ? until now.

The Franklin D. Roosevelt Four Freedoms Park, on the southern tip of 2-mile-long Roosevelt Island between the boroughs of Manhattan and Queens, is being dedicated Wednesday in a ceremony to be attended by dignitaries including former President Bill Clinton and Mayor Michael Bloomberg.

The park is named after Roosevelt's Jan. 6, 1941, State of the Union address, known as the Four Freedoms Speech. Given before America got involved in World War II, Roosevelt said the way to justify the enormous sacrifice of war was to create a world centered on four essential human freedoms: freedom of speech and expression; freedom of worship; freedom from want; and freedom from fear. The words were later incorporated into the charter of the United Nations, which Roosevelt helped create.

The park consists of a 4-acre triangular expanse of green, flanked by 120 littleleaf Linden trees leading to a colossal bronze bust of Roosevelt at the threshold of a square white-granite open-air plaza.

The statue is an enlargement of a 28-inch bust of Roosevelt, also a New York governor, created by American portrait sculptor Jo Davidson. It sits in a stone niche on the back of which a passage from the Four Freedoms speech is carved. The statue sits a mere 300 yards across the river from the United Nations headquarters.

"We hope visitors of different ages will understand that the four freedoms are the core values of democracy and that each generation has to be sure to protect them," said former U.S. Ambassador to the U.N. William vanden Heuvel, chairman of the Franklin D. Roosevelt Four Freedoms Park LLC.

The park will open to the public once arrangements for its operation and maintenance are final, officials said.

Gov. Nelson Rockefeller and Mayor John Lindsay first announced creation of the memorial park and appointed Kahn as its architect in 1973. Vanden Heuvel, 82, who was there that day, said Kahn completed the drawings a year later but died of a heart attack. That same year, Rockefeller became vice president, and the city verged on bankruptcy. With no money, the park was shelved.

The project was revived by vanden Heuvel in 2005 after an Oscar-nominated documentary, "The Architect," about Kahn by his son, Nathaniel, brought renewed interest to the memorial.

Over the next seven years, $53 million was raised, $34 million from private donors. The rest came from the city, $11 million, and the state, $8 million.

The park had been embroiled in a legal dispute with two of its major donors over how prominently their names would be displayed at the site. The Alphawood Foundation, which donated $10.8 million, reached an undisclosed settlement, while the Reed Foundation, which gave $2.9 million, won a court judgment for its name to be engraved in an area near the memorial bust as spelled out in a contract. The park had argued that "such a placement would dishonor a great president and defile Kahn's great work."

In the next several years, the park hopes to transform a nearby abandoned 19th-century smallpox hospital into a visitor's center. About 15,000 people live on the northern end of the island, which is reachable by tram or subway. The park plans to work closely with Cornell University, which is planning a graduate center on the island, on a nearby dock to transport people via water taxi and ferry.

___

Online:

http://www.fdrfourfreedomspark.org

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-17-FDR%20Park%20Dedication/id-29fd52ab8ea346e893f00257ac2a6fd8

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Annual Business Strategy Conference of the Association for ...

Google will search all of our blog sites to find just what you are looking for Have A Great Day!!!

Lincolnshire, Illinois (PRWEB) May 31, 2012

The Association for Strategic Planning (ASP) held its annual conference in Lincolnshire Illinois this month. It was a substantive conference, reported David Willden of the Strategy-Keys.com ? a popular website on business strategy and execution topics.

Alan Leeds a member of ASP?s board explained that ASP is the only not-for-profit professional association passionate about helping its members to become the true experts in in strategy development and execution for business, non-profit and government organizations.

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Tuesday, October 16, 2012

Circa?s New iOS App Will Change The Way You Consume News

The way that we consume information on the Internet has changed dramatically over the years. The main reason is because there is simply more content available to us than we could ever consume during our time on Earth. Back in the day, our only options for news were newspapers and then eventually the local TV or radio station telling us what's happening in our immediate area. Circa has launched its iOS app today, and it aims to change the way that we consume and retain information. It's a drastic approach, but it's one that could actually work.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/X3V-TbAMu7U/

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